This collective case study describes and analyzes the promising ICT-enhanced teaching and learning practices of five primary schools in different regions of the world. Each case study provides a rich description of the context in which ICT has been used to meet curriculum outcomes and engage students in the development of 21st century competencies. By linking the practices in the studied schools with particular ICT-enhanced teaching and learning activities and supporting conditions, this chapter shows a detailed account of how successful the practices are, what the participants have done to make them successful locally, and what challenges they encountered in the process. Real-world case studies such as this are critical to understanding how ICT can be used to enhance learning outcomes, and will contribute to and expand the repertoire of knowledge about ICT in primary education to better inform practices and policies.